The three protagonists are Ulysses Everett McGill (George Clooney), Delmar O'Donnell (Tim Blake Nelson), and Pete Hogwallop (John Turturro). They embark on a journey to find a hidden treasure that Ulysses claims to have stolen and buried before he was sent to prison. During their journey, they encounter a wide range of characters, including a blind prophet, a bank robber, and a trio of singing women. They also have to avoid law enforcement, including a sheriff who is determined to catch them. Throughout the film, the trio's bond is tested, and they confront their own moral values as they encounter various challenges on their quest for the treasure. The film is also notable for its use of old-time music and references to classic literature, particularly Homer's The Odyssey.